Assistant Professor of Medicine

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POSITION SPECIFICS

Position: Assistant Professor of Medicine (Non-Tenure)

Department: Department of Medicine, Penn State College of Medicine

Position Summary

Penn State College of Medicine (PSCOM) is seeking a highly skilled scientist to serve as Director of the Human iPSC & CRISPR Editing Core, a new shared research resource supporting translational and precision medicine research across the COM and Penn State Health (PSH).

This position is a dual-role appointment, with 50% effort dedicated to directing the iPSC & CRISPR Editing Core and 50% effort dedicated to research laboratory management within the Department of Medicine (DOM). This role provides an opportunity to build and lead a core facility while maintaining close engagement in active translational research programs.

Primary Responsibilities

Director, Human iPSC & CRISPR Editing Core

• Establish, lead, and operate the Human iPSC & CRISPR Editing Core.
• Oversee generation, propagation, differentiation, and characterization of human iPSCs, including iPSC-derived cardiomyocytes.
• Develop and implement CRISPR/Cas9-based genome editing approaches (knock-in, knock-out, variant modeling).
• Build and manage scalable and high-throughput iPSC-based experimental platforms.
• Provide scientific consultation to investigators on experimental design and feasibility.
• Collaborate with faculty across PSCOM, PSH, and the Department of Molecular and Precision Medicine, including alignment with organoid and precision medicine initiatives.
• Develop and maintain SOPs, quality control standards, and reproducibility practices.
• Oversee core operations, including scheduling, training, and cost-recovery activities.
• Contribute technical expertise to grant applications and progress reports.
• Ensure compliance with institutional biosafety, regulatory, and research policies.

Research Laboratory Management - Department of Medicine

• Serve as senior laboratory manager for a translational cardiovascular research laboratory.
• Oversee daily laboratory operations, including personnel supervision, purchasing, budgeting, and compliance.
• Support and execute experimental workflows involving human iPSC-derived models, genome editing, and functional assays.
• Train and mentor laboratory staff and trainees in advanced cell biology and genome editing techniques.
• Ensure continuity, efficiency, and rigor in laboratory operations and research activities.

Required Qualifications

• PhD or equivalent doctoral degree in a relevant biomedical discipline.
• Demonstrated expertise in:
  • Human iPSC generation, maintenance, and differentiation
  • CRISPR/Cas9 genome editing technologies
• Experience managing complex laboratory operations.
• Strong organizational, communication, and leadership skills.
• Ability to work collaboratively in a multidisciplinary academic research environment.

Preferred Qualifications

• Prior experience leading or contributing to a core facility or shared research resource.
• Expertise in iPSC-derived cardiomyocytes and cardiovascular disease modeling.
• Experience supporting NIH- or VA-funded research programs.
• Familiarity with core facility cost-recovery models.

Additional Information

This position offers the opportunity to play a key leadership role in building PSCOM's translational research infrastructure while remaining closely engaged in discovery science within the DOM.

BACKGROUND CHECKS/CLEARANCES

BENEFITS

For more detailed information, please visit ourBenefits Page. (Note: For Postdoctoral benefits, please see our Postdoctoral Benefits page.)

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