New

Portfolio & Program Management Senior Director

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Dec 24, 2025
Job Description General Summary: The Portfolio & Program Management Senior Director is a global role within the Portfolio & Program Management (PPM) organization. This role is a key leadership position providing strategic and operational program management leadership to the Narcolepsy Type 1 (NT1) Disease Strategy Team (DST). The incumbent is responsible for championing cross-functional program management excellence to programs across the drug development lifecycle (Research, Pre-clinical and Clinical Development, Registration and Commercialization). The incumbent is expected to apply deep subject matter expertise in program management to identify opportunities, shape objectives and drive execution of global strategies for cross-functional drug development and commercialization teams. Key Duties and Responsibilities: Provide strategic and operational program management leadership to the Narcolepsy Type 1 Disease Area Executive (DAE), Disease Strategy Team (DST) and cross-functional teams, directing activities at all stages of the program lifecycle (initiation through closeout) Drive communication cross-functionally and with senior leaders on integrated program planning topics including timelines, status, risks and interdependencies across a complex portfolio of pipeline programs. Proactively identify roadblocks and/or constraints impacting strategic imperatives or program execution and lead the team through scenario planning activities Partner with governance forums, senior leaders and/or team lead(s) to align strategy, goals and milestones with corporate objectives Propose innovative approaches, define process improvements and advise leaders on opportunities to optimize program results Determine approach and stakeholders for cross-functional decision-making and issue resolution Oversee completion of disease area deliverables and contribute to content development, when appropriate Establish project team operating norms and measure performance As a potential people manager within the organization, apply superior talent development leadership to ensure Narcolepsy Type 1 PPM team is resourced appropriately to deliver on disease area objectives while having a deep focus on developing team capabilities to enable career growth. Knowledge and Skills: Advanced knowledge of program and portfolio management principles Advanced business acumen to assess the enterprise impact of program scenarios and decisions (business case generation, financials, timeline, resources, risks, etc..) Leadership experience managing cross-functional teams with an ability to influence teams to prioritize activities and allocate resources Leadership with superior agility, adaptability, and strategic enterprise mindset Demonstrated ability to navigate ambiguity and drive strategic alignment across disease area and enterprise-level initiatives Excellent written and oral communication skills, including well-developed presentation skills Exceptional organizational skills, an ability to manage multiple priorities Strong collaboration skills to effectively interact with internal and external stakeholders at all levels in the organization Education and Experience: Typically requires a bachelor's degree in Life Sciences or a relevant field Typically requires 12 years of experience and 5 years of management experience, or the equivalent combination of education and experience Comprehensive knowledge of cross-functional pharmaceutical drug discovery, development, and commercialization across multiple disciplines #LI-HYBRID #LI-DB1 Pay Range: $242,200 - $363,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com