Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

BioMarin Pharmaceutical Inc.
life insurance, paid time off
United States, California, Petaluma
Nov 20, 2025
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience. Responsibilities: Research Support Conduct research on genetic metabolic diseases Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients Perform research and publish findings in high-impact journals and present research at major conferences Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums Write, review and contribute to study synopses, protocols, study reports and regulatory documents Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects Participate in multi-disciplinary drug development teams and may lead sub-teams Excellent written and verbal communication Ability to build/foster productive cross-functional collaborations both within and external to BioMarin Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required. Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. Share your knowledge and understanding with other team members Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. Other duties as assigned. Willingness to work on site full time including off hours and weekends based on study needs. Other duties as assigned. General requirements for the position: Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record Strong analytical, problem-solving, and decision-making skills Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities Excellent oral and written communication skills Passion for contributing your scientific skills to develop therapies for patients in need Must be able to utilize computer databases for analysis, data entry, and point of care observations Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams Must be able to work with external regulatory agencies and accreditation groups Some "off-core business hours" work required Complete all company training requirement Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks This position is an on-site critical required position Other duties as assigned Education and Experience Requirements: PhD in a related subject area with demonstrated in vivo research experience in metabolic disease Postdoctoral orindustry (2-5 years preferred) experience in genetic metabolic diseases Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. The salary range for this position is: $116,000 to $159,500. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit: https://careers.biomarin.com/benefits. Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.